@algora-pbc /claim #16

Summary

• Add a self-contained clinical adverse-event safety assistant for issue #16.
• Review synthetic clinical manuscript safety packets for underreported serious adverse events, arm-level Grade 3+ imbalance, missing event denominators, exposure-adjusted incidence gaps, missing DSMB/IRB follow-up, severity-grade claim mismatches, and downplayed safety uncertainty.
• Emit deterministic JSON, Markdown, SVG, and MP4 reviewer artifacts under clinical-adverse-event-safety-assistant/reports/.

Non-overlap

This is a clinical safety signal review slice. It is distinct from the existing broad assistant, protocol trace, image integrity, assay calibration, randomization/blinding, survival/time-to-event, missing-data/attrition, structured abstract, unit/dimension, human-subjects compliance, reporting-guideline, external-validity, qualitative-codebook, and literature-freshness submissions.

Demo video

clinical-adverse-event-safety-assistant/reports/demo.mp4

Validation

• node clinical-adverse-event-safety-assistant/test.js -> passed
• node --check clinical-adverse-event-safety-assistant/index.js -> passed
• node --check clinical-adverse-event-safety-assistant/demo.js -> passed
• node --check clinical-adverse-event-safety-assistant/test.js -> passed
• python -m py_compile clinical-adverse-event-safety-assistant/make-demo-video.py -> passed
• node clinical-adverse-event-safety-assistant/demo.js -> generated JSON/Markdown/SVG reports
• python clinical-adverse-event-safety-assistant/make-demo-video.py -> generated MP4 demo
• demo MP4 first frame decoded successfully as 1280x720
• git diff --check -> passed
• synthetic secret/email leakage scan -> passed